溶质载体转运蛋白家族30成员5抗体
规格：1mg/1ml
英文名： SLC30A5
别名： DKFZp686F23142; FLJ12496; FLJ12756; hZTL1; MGC5499; Putative uncharacterized protein DKFZp686F23142; Slc30a5; Solute carrier family 30 (zinc transporter) member 5; Solute carrier family 30 (Zinc trans
分子量： 84kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC30A5
交叉反应：Human, Mouse, Chicken,
细胞定位：
溶质载体转运蛋白家族30成员5抗体产品介绍：background: This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011] Function: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. Subunit: Heterooligomer. Interacts with ZNT6.溶质载体转运蛋白家族30成员5抗体 Subcellular Location: Golgi apparatus > trans-Golgi network membrane. Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles. Tissue Specificity: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. Similarity: Belongs to the cation diffusion 溶质载体转运蛋白家族30成员5抗体facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. Database links: Entrez Gene: 64924 Human Omim: 607819 Human SwissProt: Q8TAD4 Human SwissProt: Q9BVY8 Human Unigene: 631975 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
溶质载体转运蛋白家族30成员5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转运蛋白 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid