溶质载体家族25成员22抗体
规格：1mg/1ml
英文名： SLC25A22
别名： GC 1; GC-1; GC1; GHC1_HUMAN; Glutamate/H(+) symporter 1; Mitochondrial glutamate carrier 1; SLC25A22; Solute carrier family 25 member 22.
分子量： 38kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC25A22
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：
溶质载体家族25成员22抗体产品介绍：background: This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010] Function: nvolved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: Highly expressed in most tissues. Similarity: Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats. Database links: Entrez Gene: 504371 Cow Entrez Gene: 79751 Human Entrez Gene: 68267 Mouse Entrez Gene: 309111 Rat Omim: 609302 Human SwissProt: Q08DK4 Cow SwissProt: Q9H936 Human SwissProt: Q9D6M3 Mouse Unigene: 16050 Cow Unigene: 99486 Human Unigene: 33729 Mouse Unigene: 98367 Rat Important Note: This product as supplied is intended for溶质载体家族25成员22抗体research use only, not for use in human, therapeutic or diagnostic applications. Defects in SLC25A22 are the cause of epileptic encephalopathy early infantile type 3 (EIEE3) [MIM:609304]; also known as early myoclonic encephalopathy (EME) or neonatal epilepsy with suppression-burst pattern. Severe neonatal epilepsies with suppression-burst pattern are early-onset epileptic syndromes characterized by a typical EEG pattern. The suppression-burst pattern of the EEG is characterized by higher-voltage bursts of slow waves mixed with multifocal spikes alternating 溶质载体家族25成员22抗体with isoelectric suppression phases. EME is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis of EME is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. EME inheritance is autosomal recessive.
溶质载体家族25成员22抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid