脂肪细胞分化因子49抗体
规格：1mg/1ml
英文名： FAD49/SH3PXD2B
别名： Adapter protein HOFI; Factor for adipocyte differentiation 49; FAD49; FLJ20831; FTHS; KIAA1295; SH3 and PX domain-containing protein 2B; SH3PXD2B; SPD2B_HUMAN; TKS4; Tyrosine kinase substrate with fou
分子量： 102kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAD49/SH
交叉反应：Human, Mouse,
细胞定位：细胞浆
脂肪细胞分化因子49抗体产品介绍：background: This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015] Function: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). Subcellular Location: Cytoplasm. 脂肪细胞分化因子49抗体Cell projection > podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. Tissue Specificity: Expressed in fibroblasts. Post-translational modifications: Phosphorylated in SRC-transformed cells. DISEASE: Defects in SH3PXD2B are the cause of Frank-Ter Haar syndrome (FTHS) [MIM:249420]. It is a syndrome characterized by brachycephaly, wide fontanels, prominent forehead, hypertelorism, prominent eyes, macrocornea with or without glaucoma, full cheeks, small chin, bowing of the long bones and flexion 脂肪细胞分化因子49抗体deformity of the fingers. Similarity: Belongs to the SH3PXD2 family. Contains 1 PX (phox homology) domain. Contains 4 SH3 domains. Database links: Entrez Gene: 285590 Human Omim: 613293 Human SwissProt: A1X283 Human Unigene: 285666 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脂肪细胞分化因子49抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid