RAD21L1蛋白抗体
规格：1mg/1ml
英文名： RAD21L1
别名： dJ545L17.2; Double-strand-break repair protein rad21-like protein 1; RAD21L; RP11-314N13.7.
分子量： 63kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAD21L1
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞核 细胞浆
RAD21L1蛋白抗体产品介绍：background: Function: Meiosis-specific component of some cohesin complex. Probably required during early meiosis for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. May be involved in synapsis initiation and crossover recombination between homologous chromosomes. Subunit structure: Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3. Sequence similarities Belongs to the rad21 family. Function: Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), RAD21L1蛋白抗体while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in young mice, while it is required later as mice age. Subunit: Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3. Subcellular Location: Nucleus. Chromosome. Note: In meiotic chromosomes, localized RAD21L1蛋白抗体along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. Tissue Specificity: Specifically expressed in male and female gonads (at protein level). Similarity: Belongs to the rad21 family. Gene ID: 642636 Database links: Entrez Gene: 642636 Human SwissProt: Q9H4I0 Human Unigene: 713451 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RAD21L1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid