遮蔽蛋白肌球蛋白轻链激酶抗体
规格：1mg/1ml
英文名： OBSCN
别名： BC046431; Gm878; KIAA1556; KIAA1639; OBSCN; OBSCN_HUMAN; Obscurin; Obscurin-MLCK; Obscurin-myosin light chain kinase; Obscurin-RhoGEF; OTTMUSG00000005786; UNC89.
分子量： 868kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OBSCN
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
遮蔽蛋白肌球蛋白轻链激酶抗体产品介绍：background: The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils. 遮蔽蛋白肌球蛋白轻链激酶抗体Subcellular Location: Cytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 DH (DBL-homology) domain. Contains 3 fibronectin type-III domains. Contains 55 Ig-like (immunoglobulin-like) domains.遮蔽蛋白肌球蛋白轻链激酶抗体 Contains 1 IQ domain. Contains 2 PH domains. Contains 2 protein kinase domains. Contains 1 SH3 domain. Gene ID: 84033 Database links: Entrez Gene: 84033 Human Omim: 608616 Human SwissProt: Q5VST9 Human Unigene: 650039 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
遮蔽蛋白肌球蛋白轻链激酶抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid