视网膜前神经折叠同源框蛋白抗体
规格：1mg/1ml
英文名： RAXL1
别名： ARMD6; CORD11; Macular degeneration, age related 6, included; MGC15631; Q50 type retinal homeobox; Q50-type retinal homeobox protein; QRX; rax2; RAX2_HUMAN; RAXL1; Retina and anterior neural fold home
分子量： 21kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RAXL1
交叉反应：Human, Chimpanzee,
细胞定位：细胞核
视网膜前神经折叠同源框蛋白抗体产品介绍：Function: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter. Subcellular Location: Nucleus. DISEASE: Defects in RAX2 are the cause of age-related macular degeneration type 6 (ARMD6) [MIM:613757]. ARMD is in most patients manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders. Defects in RAX2 are the cause of cone-rod 视网膜前神经折叠同源框蛋白抗体dystrophy type 11 (CORD11) [MIM:610381]. CORD is characterized by the initial degeneration of cone photoreceptor cells, thus causing early loss of visual acuity and color vision, followed by the degeneration of rod photoreceptor cells and leading to progressive night blindness and peripheral visual field loss. Similarity: Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 468668 Chimpanzee Entrez Gene: 359713 Cow Entrez Gene: 84839 Human Omim: 610362 Human SwissProt: A2T711 Chimpanzee SwissProt: Q7YRX0 Cow SwissProt: 视网膜前神经折叠同源框蛋白抗体Q96IS3 Human Unigene: 532691 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视网膜前神经折叠同源框蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid