核钙调蛋白依赖性蛋白激酶磷酸酶抗体
规格：1mg/1ml
英文名： PPM1E
别名： Ca(2+)/calmodulin-dependent protein kinase phosphatase N; CaMKN; CaMKP-N; CaMKP-nucleus; KIAA1072; Nuclear calmodulin dependent protein kinase phosphatase; Partner of PIX 1; Partner of PIX-alpha; Part
分子量： 85kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPM1E
交叉反应：Human, Mouse, Rat,
核钙调蛋白依赖性蛋白激酶磷酸酶抗体细胞定位：细胞核 细胞浆
产品介绍：background: This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] Function: Protein phosphatase that inactivates multifunctional CaM kinases such 核钙调蛋白依赖性蛋白激酶磷酸酶抗体as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Subcellular Location: Nucleus. Cytoplasm. A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full length, minor form,核钙调蛋白依赖性蛋白激酶磷酸酶抗体 is found in the nucleus. Similarity: Belongs to the PP2C family. Contains 1 PP2C-like domain. Database links: Entrez Gene: 22843 Human SwissProt: Q8WY54 Human Unigene: 245044 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核钙调蛋白依赖性蛋白激酶磷酸酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid