亮氨酸拉链结构域蛋白ROGDI抗体
规格：1mg/1ml
英文名： ROGDI
别名： FLJ22386; KTZS; Leucine zipper domain protein; Protein rogdi homolog; rogdi; rogdi homolog (Drosophila); rogdi, Drosophila, homolog of; ROGDI_HUMAN.
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ROGDI
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
亮氨酸拉链结构域蛋白ROGDI抗体产品介绍：background: This gene encodes a protein of unknown function. Loss-of-function mutation in this gene cause Kohlschutter-Tonz syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012] Function: May act as a positive regulator of cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in spinal cord, brain, heart and bone marrow. Also expressed in fetal brain and liver. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:An autosomal recessive disorder characterized by severe global developmental delay, early-onset intractable seizures, spasticity, and amelogenesis imperfecta affecting both primary and secondary teeth and causing yellow or brown 亮氨酸拉链结构域蛋白ROGDI抗体discoloration of the teeth. Although the phenotype is consistent, there is variability. Intellectual disability is related to the severity of seizures, and the disorder can thus be considered an epileptic encephalopathy. Some infants show normal development until seizure onset, whereas others are delayed from birth. The most severely affected individuals have profound mental retardation, never acquire speech, and become bedridden early in life. Similarity: Belongs to the rogdi family. Database links: Entrez Gene: 79641 Human Entrez Gene: 66049 Mouse Entrez Gene: 亮氨酸拉链结构域蛋白ROGDI抗体287061 Rat Omim: 614574 Human SwissProt: Q9GZN7 Human SwissProt: Q3TDK6 Mouse SwissProt: Q4V7D2 Rat Unigene: 459795 Human Unigene: 27792 Mouse Unigene: 995 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亮氨酸拉链结构域蛋白ROGDI抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 细胞周期蛋白 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid