碳酸氢钠协同转运蛋白4-A5抗体
规格：1mg/1ml
英文名： SLC4A5
别名： NBC4; Electrogenic sodium bicarbonate cotransporter 4; MGC129662; NBC4; NBCe2; S4A5_HUMAN; SLC4A5; Solute carrier family 4 member 5; Solute carrier family 4 sodium bicarbonate cotransporter member 5.
分子量： 126kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC4A5
交叉反应：Human, Mouse, Rat, Chicken, Rabbit,
细胞定位：细胞膜
碳酸氢钠协同转运蛋白4-A5抗体产品介绍：background: This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] Function: Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH. Subcellular Location: Apical cell membrane. Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.碳酸氢钠协同转运蛋白4-A5抗体 Tissue Specificity: Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. Similarity: Belongs to the anion exchanger (TC 2.A.31) family. Database links: Entrez Gene: 57835 Human Entrez Gene: 232156 Mouse Entrez 碳酸氢钠协同转运蛋白4-A5抗体Gene: 297386 Rat Omim: 606757 Human SwissProt: Q9BY07 Human SwissProt: D3YX36 Mouse SwissProt: Q6RI88 Rat Unigene: 728220 Human Unigene: 214577 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
碳酸氢钠协同转运蛋白4-A5抗体研究领域：肿瘤 细胞生物 神经生物学 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid