肽酰甘氨酸2羟化酶抗体
规格：1mg/1ml
英文名： PAM/Peptidylglycine 2 hydroxylase
别名： AMD_HUMAN; PAL; PAM; Pancreatic peptidylglycine alpha amidating monooxygenase; Peptidyl alpha amidating enzyme; Peptidyl alpha hydroxyglycine alpha amidating lyase; Peptidyl-alpha-hydroxyglycine alpha
分子量： 108kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAM/Pept
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 分泌型蛋白
肽酰甘氨酸2羟化酶抗体产品介绍：background: This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008] Function: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. 肽酰甘氨酸2羟化酶抗体The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. Subcellular Location: Membrane and Secreted. Secreted from secretory granules. Similarity: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family. In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family. 肽酰甘氨酸2羟化酶抗体Contains 5 NHL repeats. Database links: Entrez Gene: 5066 Human Omim: 170270 Human SwissProt: P19021 Human Unigene: 369430 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肽酰甘氨酸2羟化酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid