RNA聚合酶II相关因子PAF49抗体
规格：1mg/1ml
英文名： PAF49
别名： A34.5; Anti sense to ERCC 1 protein; Antisense to ERCC-1 protein; ASE 1; ASE-1; ASE1; CAST; CD3 epsilon associated protein; CD3-epsilon-associated protein; CD3E antigen, epsilon polypeptide associated
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAF49
交叉反应：Human, Mouse,
细胞定位：细胞核
RNA聚合酶II相关因子PAF49抗体产品介绍：Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex. Subcellular Location: Nucleus > nucleolus. Chromosome. Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes. Post-translational modificationsRNA聚合酶II相关因子PAF49抗体: Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other group. Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol RNA聚合酶II相关因子PAF49抗体I-beta complexes but not in Pol I-alpha complexes. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the eukaryotic RPA34 RNA polymerase subunit family. Database links: Entrez Gene: 10849 Human Omim: 107325 Human SwissProt: O15446 Human Unigene: 710495 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RNA聚合酶II相关因子PAF49抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid