脑环核苷酸门控通道蛋白1/HCN1抗体
规格：1mg/1ml
英文名： BCNG1
别名： HCN1; BCNG1; Brain cyclic nucleotide gated channel 1; HAC2; Hyperpolarization activated cyclic nucleotide gated potassium channel 1; Potassium/sodium hyperpolarization activated cyclic nucleotide gate
分子量： 99kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BCNG1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞膜
脑环核苷酸门控通道蛋白1/HCN1抗体产品介绍：background: Hyperpolarization activated cation channels of the HCN gene family such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarisation and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems. Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 脑环核苷酸门控通道蛋白1/HCN1抗体MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds. Post-translational modifications: N-glycosylated. Similarity: Belongs to the immunoglobulin superfamily. ICAM family. 脑环核苷酸门控通道蛋白1/HCN1抗体ontains 5 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 348980 Database links: Entrez Gene: 348980 Human Entrez Gene: 15165 Mouse Entrez Gene: 84390 Rat Omim: 602780 Human SwissProt: O60741 Human SwissProt: O88704 Mouse SwissProt: Q9JKB0 Rat Unigene: 353176 Human Unigene: 650434 Human Unigene: 343429 Mouse Unigene: 21408 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑环核苷酸门控通道蛋白1/HCN1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid