凋亡相关蛋白1抗体
规格：1mg/1ml
英文名： RYBP
别名： AAP 1; AAP1; APAP 1; APAP-1; APAP1; Apoptin associating protein 1; Apoptin-associating protein 1; cb337; Death Effector Domain Associated Factor; Death effector domain-associated factor; Death effecto
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AAP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
凋亡相关蛋白1抗体细胞定位：细胞核 细胞浆
产品介绍：background: May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis. Function: nhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis. Subunit: Monomer. Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.凋亡相关蛋白1抗体 Interacts with CBX2, YAF2, RING1 and RNF2. Interacts with ubiquitin and ubiquitinated proteins. Interacts with ubiquitinated histone H2A (By similarity). Interacts with MDM2, and thereby inhibits ubiquitination of TP53. Identified in a ternary complex containing MDM2, TP53 and RYBP. Subcellular Location: Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies Tissue Specificity: Widely expressed with highest levels in lymphoid tissues and placenta. Post-translational modifications: Monoubiquitinated Similarity: Contains 1 RanBP2-type zinc finger. Gene ID: 23492 Database links: Entrez Gene: 23429 Human Entrez Gene: 56353 Mouse Entrez凋亡相关蛋白1抗体 Gene: 312603 Rat Omim: 607535 Human SwissProt: Q8N488 Human SwissProt: Q8CCI5 Mouse Unigene: 7910 Human Unigene: 321633 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凋亡相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid