雌**相关受体β抗体
规格：1mg/1ml
英文名： Estrogen Related Receptor beta
别名： Err 2; ERR b; ERR B2; ERR beta 2; ERR beta; Err2; ERRB 2; ERRb; ERRB2; ERRbeta 2; ERRbeta; ESR L2; ESRL 2; ESRL2; ESRRB; Estrogen receptor like 2; Estrogen receptor related 2; Estrrb; Nr3b2; Nuclear r
分子量： 56kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Estrogen
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞核
雌**相关受体β抗体产品介绍：background: Estrogen related receptor beta, a NR3 Steroid Receptor, has been shown to affect early placental development. Also it can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). It binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). Estrogen related receptor beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries. The ligand for the receptor is PPARgamma coactivator 1 (PGC-1) beta. Function: Nuclear receptor that binds DNA 雌**相关受体β抗体as monomer. Subunit: Monomer. Subcellular Location: Nuclear DISEASE: Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 2103 Database links: Entrez Gene: 490798 Dog雌**相关受体β抗体 Entrez Gene: 2103 Human Entrez Gene: 26380 Mouse Entrez Gene: 299210 Rat Omim: 602167 Human SwissProt: O95718 Human SwissProt: Q61539 Mouse SwissProt: P11475 Rat Unigene: 337489 Human Unigene: 435845 Human Unigene: 235550 Mouse Unigene: 104984 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
雌**相关受体β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 染色质和核信号 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid