双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体
规格：1mg/1ml
英文名： DUSP6
别名： Dual specificity phosphatase 6; Dual specificity phosphatase 6 isoform a; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6_HUMAN; DUSP 6; DUSP 6a; Dusp6; DUSP6a
分子量： 42kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DUSP6
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞浆
双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体产品介绍：background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding 双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Inactivates MAP kinases. Has a specificity for the ERK family. Subcellular Location: Cytoplasm. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 1848 Database links: Entrez Gene: 1848 Human Entrez Gene: 67603 Mouse Entrez Gene: 116663 Rat Omim: 602748 Human SwissProt: Q16828 Human SwissProt: 双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体Q9DBB1 Mouse SwissProt: Q64346 Rat Unigene: 298654 Human Unigene: 1791 Mouse Unigene: 4313 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid