凝集素样氧化型低密度脂蛋白受体抗体

英文名： LOX 1

别名： Lectin-type oxidized LDL receptor 1; OLR1; lectin-like low density lipoprotein receptor-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-l

分子量： 31/50kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from rabbit LOX-1

交叉反应：Human, Mouse, Rat, Cow, Rabbit,

细胞定位：细胞膜 分泌型蛋白

凝集素样氧化型低密度脂蛋白受体抗体产品介绍：background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to 凝集素样氧化型低密度脂蛋白受体抗体binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Subunit: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists. Tissue Specificity: Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues. Post-translational modifications: N-glycosylated. Similarity: Contains 1 C-type lectin domain. Gene ID: 100009322 Database links: Entrez Gene: 4973 Human Entrez凝集素样氧化型低密度脂蛋白受体抗体 Gene: 108078 Mouse Entrez Gene: 140914 Rat Omim: 602601 Human SwissProt: P78380 Human SwissProt: Q9EQ09 Mouse SwissProt: Q9XTA8 Rabbit SwissProt: O70156 Rat Unigene: 412484 Human Unigene: 293626 Mouse Unigene: 87449 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LOX-1(Lectin-like Ox-LDL receptor 1)即氧化低密度脂蛋白的内皮受体，是**受体或称清道夫受体（Scavenger Receptor,SR）家族的一种，LOX-1作为氧化低密度脂蛋白的凝集素样氧化型低密度脂蛋白受体抗体天然配体，与脂质代谢有关。

产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：心血管  **学  信号转导  

储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid