转化生长因子β2（TGFβ2）抗体
规格：1mg/1ml
英文名： TGF beta 2
别名： TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor fa
分子量： 50kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TGF beta
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
转化生长因子β2（TGFβ2）抗体产品介绍：background: Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF Alpha. It is now realized that TGF beta s mediate many cell-cell interactions that occur during embryonic development. Three TGF beta s have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.转化生长因子β2（TGFβ2）抗体 Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Subunit: Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Subcellular Location: Secreted. DISEASE: Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. 转化生长因子β2（TGFβ2）抗体Translocation t(1;7)(q41;p21) with HDAC9. Similarity: Belongs to the TGF-beta family. Gene ID: 7042 Database links: Entrez Gene: 7042 Human Entrez Gene: 21808 Mouse Omim: 190220 Human SwissProt: P21214 Cow SwissProt: P61812 Human SwissProt: P27090 Mouse Unigene: 133379 Human Unigene: 18213 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产转化生长因子β2（TGFβ2）抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 干细胞 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid