转录因子相互作用蛋白1抗体
规格：1mg/1ml
英文名： TTI1
别名： SMG10; Tel two interacting protein 1; Tel2 interacting protein 1 homolog (S. pombe); TEL2 interacting protein 1 homolog; TTI1_HUMAN.
分子量： 122kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TTI1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：
转录因子相互作用蛋白1抗体产品介绍：background: TTI1 promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. TTI1 interacts with TELO2, MTOR, ATM, ATR, PRKDC, SMG1 and TRRAP. Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 转录因子相互作用蛋白1抗体and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. Subunit: Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, SMG1, TELO2, TRRAP AND TTI2. Tissue Specificity: Widely expressed. Similarity: Belongs to the tti1 family. Gene ID: 9675 Database links: Entrez Gene: 534917 Cow Entrez Gene: 9675 Human Entrez Gene: 75425 Mouse Entrez Gene: 100154931 Pig Entrez Gene: 499935 Rat Omim: 614425 Human SwissProt: O43156 Human SwissProt: 转录因子相互作用蛋白1抗体Q91V83 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子相互作用蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid