干扰素调节因子4结合蛋白抗体
规格：1mg/1ml
英文名： DEF6/IBP
别名： DEF-6; Def6; DEFI6_HUMAN; Differentially expressed in FDCP 6 homolog; Differentially expressed in FDCP 6 homologue mouse; IBP; IRF4-binding protein; Swap70 like adapter of T cells.
分子量： 74kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DEF6/IBP
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核 细胞浆 细胞膜
干扰素调节因子4结合蛋白抗体产品介绍：background: DEF6 is a 631 amino acid protein that is widely expressed in T and B cells of the immune system. Localized to the nucleus, cytoplasm and cell membrane, DEF6 is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) that functions to activate Rho GTPases such as Rac 1, Cdc42 and Rho A. Via its ability to activate various Rho GTPases, DEF6 can regulate cell shape, movement and polarity and, through its interaction with T helper cells, DEF6 can also help mediate the immune response. DEF6 contains one PH (pleckstrin homology) domain which is required for binding to phosphatidylinositol 3,4,5-trisphosphate and subsequent recruitment to the plasma membrane. Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation 干扰素调节因子4结合蛋白抗体with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP-70 signaling. Subunit: Interacts with ZAP70 (By similarity). Interacts with IRF4, activated RAC1 and F-actin. Both the phosphorylated and non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3). Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate. Tissue Specificity: Broadly expressed in the immune system and can be detected in T and B-cells. Post-translational modifications: Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation. Similarity:干扰素调节因子4结合蛋白抗体 Contains 1 PH domain. Gene ID: 50619 Database links: Entrez Gene: 50619 Human Entrez Gene: 23853 Mouse Entrez Gene: 309642 Rat Omim: 610094 Human SwissProt: Q9H4E7 Human SwissProt: Q8C2K1 Mouse Unigene: 15476 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素调节因子4结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid