有丝分裂原诱导基因6抗体
规格：1mg/1ml
英文名： MIG6
别名： ERBB receptor feedback inhibitor 1; GENE 33; MIG6; mitogen inducible gene 6; mitogen inducible gene 6 protein; RALT; receptor-associated late transducer; ERRFI_HUMAN.
分子量： 51kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIG6
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
有丝分裂原诱导基因6抗体产品介绍：background: ERRFI1 belongs to a class of mammalian regulators of tyrosine kinase signalling, whose expression is trascriptionally controlled by receptor activation. A number of features reveal this protein as a canidate for being a signal transducing protein; proline rich sequences, consensus sequences for phosphorylation of ERK1 and ERK2, a potential binding site for 14-3-3 proteins and other potential sites for phosphorylation by protein kinase C, A and Casein kinase II. Function: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the有丝分裂原诱导基因6抗体 uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development Subunit: interacts with ERBB2. Interacts with EGFR. Subcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes. Similarity: Belongs有丝分裂原诱导基因6抗体 to the MIG6 family. Gene ID: 54206 Database links: Entrez Gene: 54206 Human Omim: 608069 Human SwissProt: Q9UJM3 Human Unigene: 605445 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
有丝分裂原诱导基因6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid