细胞膜钙ATP酶4抗体
规格：1mg/1ml
英文名： PMCA4
别名： MXRA 1; MXRA1; Plasma membrane calcium ATPase 4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium transporting ATPase 4; Plasma membrane calciu
分子量： 138kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PMCA4
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞膜
细胞膜钙ATP酶4抗体产品介绍：background: Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA3 expression is confined to brain and skeletal muscle. The PMCA4 gene is located on human chromosome 1q25 and is ubiquitously expressed. Function: This magnesium-dependent enzyme catalyzes the细胞膜钙ATP酶4抗体 hydrolysis of ATP coupled with the transport of calcium out of the cell. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Gene ID: 493 Database links: Entrez Gene: 282146 Cow Entrez Gene: 493 Human Entrez Gene: 细胞膜钙ATP酶4抗体381290 Mouse Entrez Gene: 733701 Pig Entrez Gene: 29600 Rat Omim: 108732 Human SwissProt: P23634 Human SwissProt: Q32ME1 Mouse SwissProt: Q64542 Rat Unigene: 343522 Human Unigene: 9986 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞膜钙ATP酶4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid