CD96抗体
规格：1mg/1ml
英文名： CD96
别名： CD96; Cell surface antigen CD96; DKFZp667E2122; MGC22596; T cell activated increased late expression protein; T cell surface protein tactile precursor; T cell-activated increased late expression prote
分子量： 298kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD96
交叉反应：Human,
细胞定位：细胞膜
CD96抗体产品介绍：background: CD96 antigen, also designated T cell surface protein tactile (T cell activation, increased late expression) precursor, is a type I membrane protein and is a member of the immunoglobulin supergene family of proteins. The gene encoding for the CD96 protein maps to chromosome 3q13.13-q13.2. During the late phases of the immune response, CD96 is involved in adhesive interactions of activated, both helper and cytotoxic, NK and T cells. It interacts with CD155. CD96, shows increased expression after NK and T cell activation. It can also be found actively engaging diseased cells and moving in inflamed areas after NK and T cells have moved through the endothelium. CD96 is involved in antigen presentation and/or lymphocyte activation. The protein, which may form a homodimer, is expressed on normal T cell lines and some transformed T cells. Function: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. Subunit:CD96抗体 Homodimer; disulfide-linked. Interacts with PVR. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells. DISEASE: C syndrome (CSYN) [MIM:211750]: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. {ECO:0000269|PubMed:17847009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by CD96抗体the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 Ig-like V-type (immunoglobulin-like) domains. Gene ID: 10225 Database links: Entrez Gene: 10225 Human Omim: 606037 Human SwissProt: P40200 Human Unigene: 142023 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD96抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 干细胞 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid