心脏和神经嵴衍生蛋白2抗体
规格：1mg/1ml
英文名： HAND2
别名： DHAND 2; dHAND; DHAND2; Ehand 2; Ehand2; FLJ16260; HAND 2; Hand2; autonomic nervous system and neural crest derivatives-expressed protein 2; heart; Basic helix loop helix transcription factor HAND2; b
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HAND2
交叉反应：Human, Mouse, Rat, Cow, Rabbit, Sheep,
细胞定位：
心脏和神经嵴衍生蛋白2抗体产品介绍：background: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. Function: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a 心脏和神经嵴衍生蛋白2抗体VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND1 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Subcellular Location: Nucleus. Tissue Specificity: Heart. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Gene ID: 9464 Database links: Entrez Gene: 9464 Human Entrez Gene: 15111 Mouse Entrez Gene: 64637 Rat心脏和神经嵴衍生蛋白2抗体 Entrez Gene: 58150 Zebrafish Omim: 602407 Human SwissProt: Q90690 Chicken SwissProt: P61296 Human SwissProt: Q61039 Mouse SwissProt: P61295 Rat SwissProt: P57102 Zebrafish Unigene: 388245 Human Unigene: 261588 Mouse Unigene: 430844 Mouse Unigene: 36496 Rat Unigene: 41057 Rat Unigene: 81423 Zebrafish Unigene: 8328 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
心脏和神经嵴衍生蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 发育生物学 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid