离子通道蛋白Kv4.3抗体
规格：1mg/1ml
英文名： Kv4.3
别名： KCND 3; KCND 3L; KCND 3S; KCND3; KCND3L; KCND3S; KSHIVB; Kv 4.3; Potassium ioinic channel Kv4.3; Potassium voltage gated channel Shal related subfamily member 3; Potassium voltage gated channel subfam
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Kv4.3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
离子通道蛋白Kv4.3抗体产品介绍：background: Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes (shaker, shaw, shab, and shal) have been identified in Drosophila, and each has been shown to have human homologs. This protein is a member of the potassium channel, voltage gated, shal related subfamily, members of which form voltage activated A type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. Function: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type离子通道蛋白Kv4.3抗体 potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Subunit: Homotetramer or heterotetramer with KCND1 and/or KCND2. Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Interacts with KCNE1, KCNE2, SCN1B and KCNAB1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell projection, dendrite. Tissue Specificity: Highly expressed in brain, in particular in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum and lateral geniculate and superior colliculus.离子通道蛋白Kv4.3抗体 Highly expressed in heart atrium (at protein level) and throughout the ventricle wall, in lung and vas deferens. Post-translational modifications: Regulated through phosphorylation at Ser-569 by CaMK2D (By similarity). Similarity: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. Gene ID: 3752 Database links: Entrez Gene: 3752 Human Entrez Gene: 56543 Mouse Entrez Gene: 65195 Rat Omim: 605411 Human SwissProt: Q9UK17 Human SwissProt: Q9Z0V1 Mouse SwissProt: Q62897 Rat Unigene: 666367 Human Unigene: 44530 Mouse Unigene: 10540 Rat Unigene: 202969 Rat Unigene: 214215 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
离子通道蛋白Kv4.3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid