SOS1蛋白抗体
规格：1mg/1ml
英文名： SOS1
别名： SOS1_HUMAN; Son of sevenless homolog 1; SOS-1.
分子量： 152kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
免疫原：KLH conjugated synthetic peptide derived from human SOS1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：
SOS1蛋白抗体产品介绍：Function: Promotes the exchange of Ras-bound GDP by GTP. Tissue Specificity: Expressed in gingival tissues. DISEASE: Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous SOS1蛋白抗体and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PH domain. Contains 1 Ras-GEF domain. SOS1蛋白抗体Gene ID: 6654 Database links: Entrez Gene: 6654 Human Entrez Gene: 20662 Mouse Entrez Gene: 313845 Rat Omim: 182530 Human SwissProt: Q07889 Human SwissProt: Q62245 Mouse Unigene: 709893 Human Unigene: 360004 Mouse Unigene: 60975 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SOS1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid