宫颈黏液蛋白相关蛋白抗体
规格：1mg/1ml
英文名： HIP55
别名： ABP1; Actin-binding protein 1; Cervical mucin associated protein; Cervical mucin-associated protein; Cervical SH3P7; CMAP; Dbnl; DBNL_HUMAN; Drebrin F; drebrin like; Drebrin like protein; Drebrin-F; D
分子量： 55kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HIP55
交叉反应：Human,
细胞定位：细胞浆
宫颈黏液蛋白相关蛋白抗体产品介绍：background: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. HIP-55 (HPK1-interacting protein of 55 kDa), also known as ABP1, SH3P7 or DBNL (drebrin-like), is a 430 amino acid cytoplasmic protein that belongs to the ABP1 family. HIP-55 binds to F-actin but is not involved in actin polymerization, capping or bundling. In addition to containing an ADF-H domain, HIP-55 also consists of a SH3 domain, which mediates interaction with SHANK2, SHANK3 and PRAM-1. HIP-55 acts as an actin-binding adapter protein and as a common effector of antigen receptor-signaling pathways in leukocytes. As a key component of the immunological synapse, HIP-55 regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. HIP-55 is degraded by caspases during apoptosis. Function: Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that 宫颈黏液蛋白相关蛋白抗体regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. Subunit: Interacts with SHANK2 and SHANK3. Interacts with FGD1, dynamin, MAP4K1 and PRAM1. Interacts with ANKRD54. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Cortical cytoskeleton. Associates with lamellipodial actin. Post-translational modifications: Degraded by caspases during apoptosis. Similarity: Belongs to the ABP1 family. Contains 1 ADF-H domain. Contains 1 SH3 domain. Gene ID: 28988 Database links: Entrez Gene: 28988 Human Entrez Gene: 13169 宫颈黏液蛋白相关蛋白抗体Mouse Entrez Gene: 83527 Rat Omim: 610106 Human SwissProt: Q9UJU6 Human SwissProt: Q62418 Mouse SwissProt: Q9JHL4 Rat Unigene: 436500 Human Unigene: 256925 Mouse Unigene: 4115 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
宫颈黏液蛋白相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid