固醇携带蛋白2抗体
规格：1mg/1ml
英文名： SCP2
别名： DKFZp686C12188; DKFZp686D11188; NLTP; Nonspecific lipid transfer protein; NSL TP; OTTHUMP00000010488; Propanoyl CoA C acyltransferase; SCP 2; SCP chi; SCP X; SCP2; SCPchi; SCPX; Sterol carrier protein
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCP2
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：细胞核 线粒体
固醇携带蛋白2抗体产品介绍：background: This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. 固醇携带蛋白2抗体Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Aug 2010] Function: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Subunit: Interacts with PEX5. Subcellular Location: Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues. Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. Isoform SCP2: Mitochondrion (Probable). Tissue Specificity: Liver, fibroblasts, and placenta. DISEASE: Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon固醇携带蛋白2抗体 reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: In the N-terminal section; belongs to the thiolase family. Contains 1 SCP2 domain. Gene ID: 6342 Database links: Entrez Gene: 6342 Human Entrez Gene: 20280 Mouse Entrez Gene: 25541 Rat Omim: 184755 Human SwissProt: P22307 Human SwissProt: P32020 Mouse SwissProt: P11915 Rat Unigene: 476365 Human Unigene: 379011 Mouse Unigene: 31887 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 固醇携带蛋白2(SCP2)参与了胆固醇的合成、代谢和转运过程.与胆囊固醇结石形成有关.
固醇携带蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 染色质和核信号 细胞周期蛋白 合成与降解 细胞分化 细胞骨架 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid