丝氨酸/苏氨酸SFRS9抗体
规格：1mg/1ml
英文名： SFRS9
别名： arginine/serine-rich 9; Pre mRNA splicing factor SRp30C; Pre-mRNA-splicing factor SRp30C; Serine/arginine-rich splicing factor 9; SFRS 9; Splicing factor; Splicing factor arginine/serine rich 9; splic
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SFRS9
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
丝氨酸/苏氨酸SFRS9抗体细胞定位：细胞核
产品介绍：background: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010] Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of丝氨酸/苏氨酸SFRS9抗体 MAPT/Tau exon 10. Subcellular Location: Nucleus. Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells. Tissue Specificity: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. Post-translational modifications: Extensively phosphorylated on serine residues in the RS domain. Similarity: Belongs to the splicing factor SR family. 丝氨酸/苏氨酸SFRS9抗体Contains 2 RRM (RNA recognition motif) domains. Gene ID: 8683 Database links: Entrez Gene: 8683 Human Entrez Gene: 108014 Mouse Entrez Gene: 100154637 Pig Entrez Gene: 288701 Rat Omim: 601943 Human SwissProt: Q13242 Human SwissProt: Q9D0B0 Mouse SwissProt: Q5PPI1 Rat Unigene: 706889 Human Unigene: 728777 Human Unigene: 287826 Mouse Unigene: 136718 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸SFRS9抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid