FAS凋亡抑制分子3抗体
规格：1mg/1ml
英文名： FAIM3
别名： Faim3; FAIM3_HUMAN; Fas apoptotic inhibitory molecule 3; Fc mu receptor; FCMR; IgM Fc receptor; Immunoglobulin mu Fc receptor; Regulator of Fas induced apoptosis; Regulator of Fas-induced apoptosis To
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAIM3
交叉反应：Human,
细胞定位：细胞膜 分泌型蛋白
FAS凋亡抑制分子3抗体产品介绍：background: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Tissue specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis FAS凋亡抑制分子3抗体BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. Subcellular Location: Isoform 1: Membrane; Single-pass membrane protein. Isoform 3: Secreted. Note=Detected in the serum. Tissue Specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2,FAS凋亡抑制分子3抗体 HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. Similarity: Contains 1 Ig-like (immunoglobulin-like) domain. Gene ID: 9214 Database links: Entrez Gene: 9214 Human Omim: 606015 Human SwissProt: O60667 Human Unigene: 58831 Human Unigene: 728324 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FAS凋亡抑制分子3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid