去整合素样金属蛋白酶9抗体
规格：1mg/1ml
英文名： ADAM9
别名： A disintegrin and metalloproteinase domain 9; A disintegrin and metalloproteinase domain 9; ADAM 9 antibody ADAM metallopeptidase domain 9; Cellular disintegrin related protein; Disintegrin and metall
分子量： 88kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADAM9
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞膜 分泌型蛋白
去整合素样金属蛋白酶9抗体产品介绍：background: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq]. Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP. [COFACTOR] Binds 1 zinc ion per subunit (Probable). Subunit: Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. DISEASE: Cone-rod dystrophy 9 (CORD9) [MIM:612775]:去整合素样金属蛋白酶9抗体 An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Note=The disease i去整合素样金属蛋白酶9抗体s caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. Gene ID: 8754 Database links: Entrez Gene: 8754 Human Entrez Gene: 11502 Mouse Entrez Gene: 290834 Rat Omim: 602713 Human SwissProt: Q13443 Human SwissProt: Q61072 Mouse Unigene: 591852 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
去整合素样金属蛋白酶9抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 锌指蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid