吞噬细胞运动蛋白2抗体
规格：1mg/1ml
英文名： ELMO2
别名： CED 12; Ced 12 homolog 2; CED 12 homolog A; CED 12A; CED-12; ced-12 homolog 2; CED12; CED12 homolog A; CED12A; ELMO 2; ELMO-2; ELMO2; ELMO2_HUMAN; Engulfment and cell motility 2 (ced 12 homolog, C. el
分子量： 83kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ELMO2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
吞噬细胞运动蛋白2抗体产品介绍：background: Elmo (engulfment and cell motility) proteins share similarity to C. elegans CED-12. The C. elegans genes ced-2, ced-5, ced-10, and ced-12 and their mammalian homologs CRKII, DOCK1, RAC1 and ELMO mediate cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility. Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases. Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide吞噬细胞运动蛋白2抗体exchange factor (GEF) activity of DOCK1. Subunit: Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2. Subcellular Location: Cytoplasm. Cytoplasm; cytosol. Membrane. Tissue Specificity: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. Similarity: Contains 1 ELMO domain. Contains 1 PH domain. Gene ID: 63916 Database links: Entrez Gene: 508361 Cow Entrez Gene: 63916 Human Entrez Gene: 140579 Mouse Entrez Gene: 362271 Rat Omim: 606421 Human 吞噬细胞运动蛋白2抗体SwissProt: A4FUD6 Cow SwissProt: Q96JJ3 Human SwissProt: Q8BHL5 Mouse Unigene: 210469 Human Unigene: 35064 Mouse Unigene: 2097 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
吞噬细胞运动蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid