凋亡加强结构域蛋白12抗体
规格：1mg/1ml
英文名： CARD12
别名： LRR; CARD 12; CARD; CARD LRR and NACHT containing protein 1; CARD LRR and NACHT containing protein; CARD12; Caspase recruitment domain containing protein 12; Caspase recruitment domain-containing prot
分子量： 116kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CARD12
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
凋亡加强结构域蛋白12抗体产品介绍：Function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. Subunit: Component of the NLRC4 inflammasome. Homooligomer. Interacts with ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR. Subcellular Location: Cytoplasm. Cytoplasm, cytosol. Note=Cytoplasmic filaments. Tissue Specificity: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only凋亡加强结构域蛋白12抗体 detected in brain. Post-translational modifications: Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro. Similarity: Contains 1 CARD domain. Contains 14 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Gene ID: 凋亡加强结构域蛋白12抗体58484 Database links: Entrez Gene: 58484 Human Entrez Gene: 268973 Mouse Entrez Gene: 298784 Rat Omim: 606831 Human SwissProt: Q9NPP4 Human Unigene: 574741 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
凋亡加强结构域蛋白12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid