蛋白磷酸酶1调节亚基3B抗体
规格：1mg/1ml
英文名： PPP1R3B
别名： FLJ14005; FLJ34675; GL; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL; Hepatic glycogen targeting subunit G(L); Hepatic glycogen-targeting protein phosphatase 1 regulatory sub
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP1R3B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
蛋白磷酸酶1调节亚基3B抗体产品介绍：background: This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011] Function: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1.蛋白磷酸酶1调节亚基3B抗体 Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. Subunit: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes withdebranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity). Tissue Specificity: Highly expressed in liver. Expressed moderately in skeletal muscle and myotubes (at protein level). Expressed predominantly in heart and skeletal muscle. Expressed moderately in liver. Expressed weakly in placenta, lung and kidney. Similarity: Contains 1 CBM21 (carbohydrate binding type-21)蛋白磷酸酶1调节亚基3B抗体 domain. Gene ID: 79660 Database links: Entrez Gene: 514428 Cow Entrez Gene: 79660 Human Entrez Gene: 244416 Mouse Entrez Gene: 192280 Rat Omim: 610541 Human SwissProt: A6QNP3 Cow SwissProt: Q86XI6 Human SwissProt: Q8C767 Mouse SwissProt: Q6IN01 Rat Unigene: 458513 Human Unigene: 247126 Mouse Unigene: 30046 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白磷酸酶1调节亚基3B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit