蛋白磷酸酶1调节亚基抑制蛋白16B抗体
规格：1mg/1ml
英文名： PPP1R16B
别名： ANKRD4; Ankyrin repeat domain containing protein 4; ankyrin repeat domain protein 4; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; hTIMAP; KIAA0823; PP16B_HUMAN; PPP1R16B; Protei
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP1R16B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
蛋白磷酸酶1调节亚基抑制蛋白16B抗体产品介绍：background: The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Subcellular Location:蛋白磷酸酶1调节亚基抑制蛋白16B抗体 Cell membrane. Cell membrane. Nucleus. Co-localizes with RPSA/LAMR1 in the cell membrane. Tissue Specificity: Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis. Post-translational modifications: Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity. Similarity: Contains 5 ANK repeats. Gene ID: 26051 Database蛋白磷酸酶1调节亚基抑制蛋白16B抗体 links: Entrez Gene: 26051 Human Entrez Gene: 228852 Mouse Omim: 613275 Human SwissProt: Q96T49 Human SwissProt: Q8VHQ3 Mouse Unigene: 45719 Human Unigene: 150540 Mouse Unigene: 485085 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白磷酸酶1调节亚基抑制蛋白16B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid