抑癌基因NDRG2抗体
规格：1mg/1ml
英文名： NDRG2
别名： N-myc downstream regulated gene 2; NDRG2; KIAA1248; SYLD; Protein NDRG2; Protein Ndr2; NDRG1-related protein; Antidepressant-related protein ADRG123. N myc downstream regulated gene 2; N myc downstrea
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NDRG2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
细胞定位：细胞浆
抑癌基因NDRG2抗体产品介绍：background: his gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. Subunit: Interacts with CTNNB1. Subcellular Location: Cytoplasm. 抑癌基因NDRG2抗体Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons. Tissue Specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer抑癌基因NDRG2抗体 disease (at protein level). Similarity: Belongs to the NDRG family. Gene ID: 57447 Database links: Entrez Gene: 57447 Human Entrez Gene: 29811 Mouse Entrez Gene: 171114 Rat Omim: 605272 Human SwissProt: Q9UN36 Human SwissProt: Q9QYG0 Mouse SwissProt: Q8VBU2 Rat Unigene: 525205 Human Unigene: 26722 Mouse Unigene: 3407 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
抑癌基因NDRG2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 细胞周期蛋白 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid