PRDM锌指转录因子PRDM14抗体
规格：1mg/1ml
英文名： PRDM14
别名： MGC59730; PFM 11; PFM11; PFM11; PR domain containing 14; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing protein 14; PRD14_HUMAN; PRDM 14; PRDM14.
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PRDM14
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞核
PRDM锌指转录因子PRDM14抗体产品介绍：background: This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011] Function: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1PRDM锌指转录因子PRDM14抗体 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. Subcellular Location: Nucleus. Tissue Specificity: Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level). Similarity: Contains 6 C2H2-type zinc fingers. Contains 1 SET domain. PRDM锌指转录因子PRDM14抗体Gene ID: 63978 Database links: Entrez Gene: 100140032 Cow Entrez Gene: 486988 Dog Entrez Gene: 63978 Human Entrez Gene: 383491 Mouse Entrez Gene: 100519142 Pig Entrez Gene: 297769 Rat Omim: 611781 Human SwissProt: Q9GZV8 Human SwissProt: E9Q3T6 Mouse Unigene: 287532 Human Unigene: 309380 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：PRDM锌指转录因子PRDM14抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid