蛋白磷酸酶6调节亚基C抗体
规格：1mg/1ml
英文名： PPP6C
别名： FLJ92648; MGC12249; PP 6; PP6; PP6C; PPP 6; PPP 6C; PPP6; PPP6_HUMAN; Ppp6c; Protein phosphatase 6 catalytic subunit; Serine/threonine protein phosphatase 6; Serine/threonine protein phosphatase catal
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP6C
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆
蛋白磷酸酶6调节亚基C抗体产品介绍：background: This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008] Function: Catalytic subunit of protein phospatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Subunit: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1,蛋白磷酸酶6调节亚基C抗体 PPP6R2 and PPP6R3. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. Similarity: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily. Gene ID: 5537 Database links: Entrez Gene: 5537 Human Entrez Gene: 511058 Cow Entrez Gene: 608922 DogEntrez Gene: 67857 Mouse Entrez Gene: 100153256 Pig Entrez Gene: 171121 Rat Entrez Gene: 734439 Xenopus laevis Entrez蛋白磷酸酶6调节亚基C抗体 Gene: 393980 Zebrafish Omim: 612725 Human SwissProt: O00743 Human SwissProt: Q9CQR6 Mouse SwissProt: Q64620 Rat Unigene: 728922 Human Unigene: 389242 Mouse Unigene: 392662 Mouse Unigene: 9573 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白磷酸酶6调节亚基C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid