蛋白磷酸酶2调节亚基2D抗体
规格：1mg/1ml
英文名： PPP2R2D
别名： 2ABD_HUMAN; MDS026; PP2A subunit B isoform B55-delta; PP2A subunit B isoform delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PPP2R2D; Protein phosphatase 2 regulatory subuni
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PPP2R2D
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞浆
蛋白磷酸酶2调节亚基2D抗体产品介绍：Function: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Subunit: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ENSA (when phospho蛋白磷酸酶2调节亚基2D抗体rylated at 'Ser-67') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity). Subcellular Location: Cytoplasm. Similarity: Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats. Gene ID: 55844 Database links: Entrez Gene: 423970 Chicken Entrez Gene: 55844 Human Entrez Gene: 52432 Mouse Entrez Gene: 246255 Rat Entrez Gene: 379305 Xenopus laevis Entrez Gene: 448324 Xenopus tropicalis Entrez Gene: 327263 Zebrafish Omim: 613992 Human SwissProt: Q5ZIY5 Chicken SwissProt:蛋白磷酸酶2调节亚基2D抗体 Q5E9Q7 Cow SwissProt: Q4R8L3-2 Cynomolgus Monkey SwissProt: Q66LE6 Human SwissProt: Q925E7 Mouse SwissProt: Q5R4A2 Orangutan SwissProt: Q29090 Pig SwissProt: P63150 Rabbit SwissProt: P56932 Rat SwissProt: Q7ZX64 Xenopus laevis SwissProt: Q6DIY3 Xenopus tropicalis SwissProt: Q6NY64 Zebrafish Unigene: 380372 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白磷酸酶2调节亚基2D抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid