T细胞**瘤浸润和转移蛋白2抗体
规格：1mg/1ml
英文名： TIAM2
别名： FLJ41865; OTTHUMP00000017472; SIF and TIAM1 like exchange factor; SIF and TIAM1-like exchange factor; STEF; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing prote
分子量： 190kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIAM2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
T细胞**瘤浸润和转移蛋白2抗体产品介绍：background: This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along theT细胞**瘤浸润和转移蛋白2抗体 altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA. Subunit: Interacts with MAP1A, MAP1B, PARP1 and YWHAE. Interacts with CD44, PARD3 and MAPK8IP2 (By similarity). Subcellular Location: Cytoplasm. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Localizes to the plasma membrane in neurites. Tissue Specificity: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis. Post-translational modifications: Phosphorylated on serine and threonine residues. Phosphorylated on Thr-1648 by Rho-kinase. Its phosphorylation by Rho-kinase inhibits its guanine nucleotide exchange activity, T细胞**瘤浸润和转移蛋白2抗体its interaction with MAP1A, MAP1B, PARP1 and YWHAE and reduces its ability to promote neurite growth. Similarity: Belongs to the TIAM family. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PH domains. Contains 1 RBD (Ras-binding) domain. Gene ID: 26230 Database links: Entrez Gene: 26230 Human Entrez Gene: 24001 Mouse Entrez Gene: 308142 Rat Omim: 604709 Human SwissProt: Q8IVF5 Human SwissProt: Q6ZPF3 Mouse Unigene: 586279 Human Unigene: 137134 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
T细胞**瘤浸润和转移蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 **细胞 t-**细胞 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid