TIP60相关蛋白54α抗体
规格：1mg/1ml
英文名： TIP49A
别名： 49 kDa TATA box binding protein interacting protein; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic p
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIP49A
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞核 细胞浆 细胞膜
TIP60相关蛋白54α抗体产品介绍：Function: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able toTIP60相关蛋白54α抗体 bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation. Subcellular Location: Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. Tissue Specificity: Ubiquitously expressed with high expression in heart,TIP60相关蛋白54α抗体 skeletal muscle and testis. Similarity: Belongs to the ruvB family. Gene ID: 8607 Database links: Entrez Gene: 416022 Chicken Entrez Gene: 8607 Human Entrez Gene: 56505 Mouse Entrez Gene: 65137 Rat Entrez Gene: 317679 Zebrafish Omim: 603449 Human SwissProt: Q9Y265 Human SwissProt: P60122 Mouse SwissProt: P60123 Rat SwissProt: Q8AWW7 Zebrafish Unigene: 272822 Human Unigene: 42195 Mouse Unigene: 86410 Rat Unigene: 77619 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TIP60相关蛋白54α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid