TBP相互作用蛋白TIP120A抗体
规格：1mg/1ml
英文名： TIP120A
别名： CAND 1; Cand1; CAND1_HUMAN; Cullin associated and neddylation dissociated 1; Cullin associated and neddylation dissociated protein 1; Cullin associated NEDD8 dissociated protein 1; Cullin-associated a
分子量： 136kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIP120A
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞核 细胞浆
TBP相互作用蛋白TIP120A抗体产品介绍：Function: Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins. Subunit: Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with TBP相互作用蛋白TIP120A抗体cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Subcellular Location: Cytoplasm Nucleus. Similarity: Belongs to the CAND family. Contains 27 HEAT repeats. Gene ID: 55832 Database links: EntrezTBP相互作用蛋白TIP120A抗体 Gene: 452060 Chimpanzee Entrez Gene: 538086 Cow Entrez Gene: 55832 Human Entrez Gene: 71902 Mouse Entrez Gene: 100173509 Orangutan Entrez Gene: 117152 Rat Omim: 607727 Human SwissProt: A7MBJ5 Cow SwissProt: Q86VP6 Human SwissProt: Q6ZQ38 Mouse SwissProt: Q5R6L5 Orangutan SwissProt: P97536 Rat Unigene: 546407 Human Unigene: 203965 Mouse Unigene: 32934 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TBP相互作用蛋白TIP120A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid