蔗糖发酵蛋白2样蛋白1抗体
规格：1mg/1ml
英文名： SmarcAL1
别名： HARP; HepA Related Protein; HepA-related protein; hHARP; SIOD; SMAL1_HUMAN; SMARCA like Protein 1; smarcal1; Sucrose nonfermenting protein 2 like 1; Sucrose nonfermenting protein 2-like 1; SWI/SNF Rel
分子量： 106kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SmarcAL1
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞核
蔗糖发酵蛋白2样蛋白1抗体产品介绍：background: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008] Function: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Subunit: Interacts with RPA2; the interaction is direct and mediates the recruitment by the RPA complex of SMARCAL1 to sites of DNA damage. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed, with high levels in testis. DISEASE: Defects in SMARCAL1 are a cause 蔗糖发酵蛋白2样蛋白1抗体of Schimke immuno-osseous dysplasia (SIOD) [MIM:242900]. SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Similarity: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. Contains 2 HARP domains. Contains 1蔗糖发酵蛋白2样蛋白1抗体 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Gene ID: 50485 Database links: Entrez Gene: 338072 Cow Entrez Gene: 50485 Human Entrez Gene: 54380 Mouse Entrez Gene: 316477 Rat Omim: 606622 Human SwissProt: Q9TTA5 Cow SwissProt: Q9NZC9 Human SwissProt: Q8BJL0 Mouse SwissProt: B4F769 Rat Unigene: 516674 Human Unigene: 274232 Mouse Unigene: 34679 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产蔗糖发酵蛋白2样蛋白1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 t-**细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid