雌**调节基因1抗体
规格：1mg/1ml
英文名： CUZD1
别名： CUB and zona pellucida-like domain-containing protein 1: CUB and ZP domain-containing protein 1: CUZD1: ERG-1: Transmembrane protein UO-44: UNQ224/PRO257: UO-44.
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SERF1
交叉反应：Human, Mouse, Rat,
雌**调节基因1抗体细胞定位：细胞浆 细胞膜 细胞外基质
产品介绍：background: CUZD1 is a 607 amino acid single-pass type I membrane protein that contains two CUB domains and a ZP (zona-pellucida) domain. Expressed in pancreas and epithelium of ovary, CUZD1 is found at high levels in ovarian tumors where it is thought to inhibit cell attachment and proliferation. CUZD1 is suggested to play a role in cell motility, cell-cell interactions and/or interactions with the extracellular matrices. Existing as three alternatively spliced isoforms, CUZD1 is encoded by a gene located on human chromosome 10. Making up 4.5% of the human genome, chromosome 10 encodes roughly 800 genes including PTEN, a tumor suppressor gene that has been linked to the development of Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is雌**调节基因1抗体 characterized by extreme photosensitivity and premature aging. Function: CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells. Subcellular Location: Cytoplasmic vesicle > secretory vesicle membrane. Associated with zymogen granule雌**调节基因1抗体 membranes. Tissue Specificity: Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue. Similarity: Contains 2 CUB domains. Contains 1 ZP domain. Database links: Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：雌**调节基因1抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid