**原转化酶5/6抗体
规格：1mg/1ml
英文名： PC5/PC6
别名： FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; PCSK5; PCSK5_HUMAN; Prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; Proprotein convertase PC5; Proprotein convertase subtilisin/kex
分子量： 101kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PC5/PC6
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：分泌型蛋白
**原转化酶5/6抗体产品介绍：background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a**原转化酶5/6抗体 protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014] Function: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Subcellular Location: Secreted. Tissue Specificity: Expressed in T-lymphocytes. Similarity: Belongs to the peptidase S8 family. Contains 1 homo B/P domain. Contains 1 PLAC domain. Gene ID: 5125 Database links: Entrez Gene: 5125 Human Entrez Gene: **原转化酶5/6抗体18552 Mouse Entrez Gene: 116548 Rat Omim: 600488 Human SwissProt: Q92824 Human SwissProt: Q04592 Mouse SwissProt: P41413 Rat Unigene: 368542 Human Unigene: 3401 Mouse Unigene: 104002 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
**原转化酶5/6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid