磷酸化视网膜色素变性蛋白4抗体
规格：1mg/1ml
英文名： phospho-Rhodopsin (Ser334)
别名： Rhodopsin (phospho S334); p-Rhodopsin (phospho S334); CSNBAD1; MGC138309; MGC138311; OPN 2; OPN2; opsd; OPSD_HUMAN; Opsin 2; opsin 2; Opsin 2 rod pigment; Opsin-2; Opsin2; Retinitis Pigmentosa 4; Reti
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Rat, Rabbit,
细胞定位：细胞膜
磷酸化视网膜色素变性蛋白4抗体产品介绍：background: Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008] Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis 磷酸化视网膜色素变性蛋白4抗体to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. Subcellular Location: Membrane. Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia. Tissue Specificity: Rod shaped photoreceptor cells which mediates vision in dim light. Post-translational modifications: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Contains one covalently linked retinal chromophore磷酸化视网膜色素变性蛋白4抗体. DISEASE: Retinitis pigmentosa 4. Night blindness, congenital stationary, autosomal dominant 1 Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Gene ID: 6010 Database links: Entrez Gene: 6010 Human Entrez Gene: 212541 Mouse Entrez Gene: 24717 Rat Omim: 180380 Human SwissProt: P08100 Human SwissProt: P15409 Mouse SwissProt: P51489 Rat Unigene: 247565 Human Unigene: 2965 Mouse Unigene: 406156 Mouse Unigene: 92530 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化视网膜色素变性蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 干细胞 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid