G蛋白信号转导调节因子18抗体
规格：1mg/1ml
英文名： RGS18
别名： Regulator of G protein signalling 13; Regulator of G Protein Signalling 18; Regulator of G-protein signaling 18; RGS 18; RGS13; RGS18; RGS18_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RGS18
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞浆
G蛋白信号转导调节因子18抗体产品介绍：background: This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits therebyG蛋白信号转导调节因子18抗体driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver. Similarity:G蛋白信号转导调节因子18抗体 Contains 1 RGS domain. Gene ID: 64407 Database links: Entrez Gene: 64407 Human Entrez Gene: 64214 Mouse Entrez Gene: 289076 Rat Omim: 607192 Human SwissProt: Q9NS28 Human SwissProt: Q99PG4 Mouse SwissProt: Q4L0E8 Rat Unigene: 440890 Human Unigene: 253927 Mouse Unigene: 202353 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白信号转导调节因子18抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid