G蛋白信号转导调节因子10抗体
规格：1mg/1ml
英文名： RGS10
别名： Regulator of G protein signaling 10; Regulator of G protein signalling 10; Regulator of G-protein signaling 10; RGS10; RGS10_HUMAN.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RGS10
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
G蛋白信号转导调节因子10抗体产品介绍：background: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G proteinG蛋白信号转导调节因子10抗体 alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. Post-translational modifications: Isoform 3 is phosphorylated on Ser-16. Similarity: Contains 1 RGS domain. Gene ID: 6001 Database links: Entrez Gene: 614550 Cow Entrez Gene: 6001 Human Entrez Gene: 67865 Mouse Entrez Gene:G蛋白信号转导调节因子10抗体448968 Pig Entrez Gene: 54290 Rat Omim: 602856 Human SwissProt: Q2KHW7 Cow SwissProt: O43665 Human SwissProt: Q9CQE5 Mouse SwissProt: P49806 Rat Unigene: 501200 Human Unigene: 18635 Mouse Unigene: 23957 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白信号转导调节因子10抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid