鸟嘌呤核苷酸交换因子RGNEF抗体
规格：1mg/1ml
英文名： RGNEF
别名： 190 kDa guanine nucleotide exchange factor; guanine nucleotide exchange factor, 190-KD; KIAA1998; p190-RhoGEF; p190RhoGEF; RGNEF; RGNEF, mouse, homolog of; RGNEF_HUMAN; Rho guanine nucleotide exchange
分子量： 192kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RGNEF
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
鸟嘌呤核苷酸交换因子RGNEF抗体产品介绍：background: This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis. Subunit: Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. 鸟嘌呤核苷酸交换因子RGNEF抗体Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA. Subcellular Location: Cytoplasm. Cell membrane. Colocalizes with the microtubule radial and cortical systems. Post-translational modifications: Phosphorylated on tyrosine upon stimulation of cells by laminin. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain.鸟嘌呤核苷酸交换因子RGNEF抗体 Contains 1 phorbol-ester/DAG-type zinc finger. Gene ID: 64283 Database links: Entrez Gene: 64283 Human Omim: 612790 Human SwissProt: Q8N1W1 Human Unigene: 482521 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鸟嘌呤核苷酸交换因子RGNEF抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid