REPS2蛋白抗体
规格：1mg/1ml
英文名： REPS2
别名： OTTHUMP00000022995; Partner of Ral binding protein 1; Partner of RalBP1; POB1; RALBP1 associated Eps domain containing 2; RALBP1 interacting protein 2; RALBP1-associated Eps domain-containing protein
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human REPS2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
REPS2蛋白抗体产品介绍：background: The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Involved in growth factor signaling through its influence on the Ral signaling pathway. Subunit: Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1. Subcellular Location: Cytoplasmic. Tissue Specificity: Expressed at high levels in the cerebrum, cerebellum, lungREPS2蛋白抗体, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer. Post-translational modifications: EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as REPS2蛋白抗体GRB2. Similarity: Contains 1 EF-hand domain. Contains 2 EH domains. Gene ID: 9185 Database links: Entrez Gene: 526887 Cow Entrez Gene: 100056954 Horse Entrez Gene: 9185 Human Entrez Gene: 100353871 Rabbit Entrez Gene: 363466 Rat Omim: 300317 Human SwissProt: Q8NFH8 Human Unigene: 186810 Human Unigene: 207682 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：REPS2蛋白抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 信号转导 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid