RNA结合蛋白25抗体
规格：1mg/1ml
英文名： RBM25
别名： Arg/Glu/Asp rich protein, 120 kDa; Arg/Glu/Asp-rich protein of 120 kDa; fSAP94; functional spliceosome-associated protein 94; NET52; Protein S164; Rbm25; RBM25_HUMAN; RED120; RNA binding motif protein
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RBM25
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
RNA结合蛋白25抗体产品介绍：Function: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Subcellular Location: Nucleus speckle. RNA结合蛋白25抗体Cytoplasm. Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint. Post-translational modifications: Sumoylated. Similarity: Contains 1 PWI domain. Contains 1 RRM (RNA recognition motif) RNA结合蛋白25抗体domain. Gene ID: 58517 Database links: Entrez Gene: 58517 Human Entrez Gene: 67039 Mouse Entrez Gene: 366693 Rat Omim: 612427 Human SwissProt: P49756 Human SwissProt: B2RY56 Mouse Unigene: 531106 Human Unigene: 46005 Mouse Unigene: 95285 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：RNA结合蛋白25抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid